Gene Therapy for Preventing Progressive Sensorineural Hearing Loss and Restoring Hearing

Grant number: 1024350 | Funding period: 2012 - 2015

Completed

Abstract

This proposal aims to study the clinical feasibility and safety of gene therapy in the guinea pig cochlea for preventing progressive hearing loss and restoring hearing. Two cell survival genes (GDNF and BDNF) will be studied for preserving sensory (hair) cells and hearing nerves, while a gene called Atoh1 will be investigated for its ability to regenerate new hair cells and restore hearing after the onset of progressive hearing loss.

Related publications (8)

Scholarly works icon

2.49 - Gene Therapy Approaches for Cochlear Repair

RT Richardson, N Gunewardene

2020-01-01

An estimated 466 million people worldwide are affected by hearing loss. The impact on quality of life is large, with hearing loss ..

Scholarly works icon

New molecular therapies for the treatment of hearing loss

Y Ma, AK Wise, RK Shepherd, RT Richardson

2019-08-01

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..

Scholarly works icon

Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss

RT Richardson, AC Thompson, AK Wise, K Needham

2017-02-01

Introduction: Electrical stimulation has long been the most effective strategy for evoking neural activity from bionic devices and..

Scholarly works icon

Atoh1 gene therapy in the cochlea for hair cell regeneration

RT Richardson, PJ Atkinson

2015-03-01

Introduction: The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory ne..

Scholarly works icon

Treating hearing disorders with cell and gene therapy

LN Gillespie, RT Richardson, BA Nayagam, AK Wise

2014-12-01

Hearing loss is an increasing problem for a substantial number of people and, with an aging population, the incidence and severity..

Scholarly works icon

Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs

PJ Atkinson, AK Wise, BO Flynn, BA Nayagam, RT Richardson

2014-07-18

The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promo..

Scholarly works icon

Gene therapy boosts the bionic ear

RK Shepherd, AK Wise

2014-04-23

Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear (Pinyon et al., this ..

Scholarly works icon

Viability of long-term gene therapy in the cochlea

PJ Atkinson, AK Wise, BO Flynn, BA Nayagam, RT Richardson

2014-04-22

Gene therapy has been investigated as a way to introduce a variety of genes to treat neurological disorders. An important clinical..